Manchester City are now the clear favourites to regain the English Premier League title after their stunning 4-1 demolition of arch-rivals Manchester United on Sunday.
David Moyes' first Manchester derby in charge of the reigning title holders turned into a nightmare as United - without the injured Robin Van Persie - were humiliated by City with their only goal a late consolation in the 87th minute from Wayne Rooney.
Incredibly the club that has won 13 of the past 21 EPL titles under their legendary former manager Sir Alex Ferguson is now sitting in eighth spot on the table after five matches - five points behind joint leaders Arsenal and Spurs.
But while there is a long way to go, the bookies have been quick to react with United now out to their biggest odds to win the title in years - given they have already failed to beat another of the leading contenders Chelsea [at home] so far this season.
City - who won the 2011-12 EPL crown to end a 44-year drought - firmed from $3.50 into $2.87 to win the title at leading bookmakers bet365 following their demolition of United.
Chelsea maintained second favouritism but eased slightly from $3.75 to $4 after beating Fulham 2-0 on Saturday to move into fourth spot, trailing City in third spot by goal difference only.
However United, while still third favourites, have now eased from $4.50 to $5 in title betting.
Arsenal continue to firm, in from $8.50 to $7, as their great start to the season continued with a 3-1 home win over Stoke on Saturday.
And their north London rivals Tottenham firmed from $13 into $11 to win their first title since 1961 after a courageous 1-0 win away to Cardiff, thanks to a last-minute goal from Brazilian Paulinho.
Spurs are now on the fifth line of title betting, ahead of Liverpool - who eased from $9 to $13 - following a shock home loss to Southampton.
In what is shaping as the most exciting title race in years - with six legitimate contenders - United are facing their greatest test in decades but are definitely great value at present for those fans who believe the Red Devils will inevitably regain their usual form.
But while there is a genuine six-way fight for the title this season, the gap between the top six and the rest is definitely reflected in title betting, with Everton next in the market at $151 at bet365 while every other club is $1000 or more.
However, bet365 are also offering betting on the title, without the top six involved, and there is some real value here.
While Everton are the $1.80 favourites to finish the highest on the table of the remaining 14 clubs, Southampton look real value in that market at $7 with the Saints really on the improve and just having knocked over Liverpool at Anfield.
In the relegation market, Crystal Palace and Sunderland already look prime candidates to go down and are the clear favourites at $1.33 and $2 at bet365 but the battle for the third relegation place looks like offering some real value with Hull next at $2.37, followed by Cardiff at $3 and Norwich at $3.60.
However Fulham - who sit in the relegation zone alongside Palace and Sunderland - also look real value in that market at $5.50.
*Note prices subject to change