Two of the world's best strikers - Liverpool's Luiz Suarez and Monaco's Radamel Falcao - will go head-to-head when Uruguay hosts Colombia on Wednesday morning [AEST] in a huge South American World Cup qualifier.
Uruguay - which finished fourth at the last World Cup in South Africa in 2010 - are facing their usual difficult battle to qualify from the tough Conmebol confederation.
With only the top four teams to qualify automatically for Brazil 2014, Uruguay are in fifth place with 19 points from 13 games, two points behind fourth placed Ecuador.
If Uruguay were to finish in fifth spot then the two-time World Cup winners would face a two-legged play-off against either Jordan or Uzbekistan for a place in Brazil - just as they did when they twice met Australia in a play-off for the World Cup, winning in 2002 and losing in 2006.
But with Suarez in red-hot form, Uruguay will go into Tuesday night's clash against Colombia as the $2.05 favourites at Bet365.
Colombia are equal top of the group - with Argentina on 26 points from 13 games - knowing even a draw in Montevideo will guarantee their first trip to the World Cup finals since 1998.
Suarez is the leading scorer in South American World Cup qualifying with ten, including both goals in Friday night's crucial 2-1 away win against Peru, while Colombia are coming off a 1-0 home win against Ecuador.
However, Colombia thrashed Uruguay 4-0 in Colombia earlier in the campaign, with Falcao scoring after just two minutes that day - one of seven goals the former Porto and Atletico Madrid striker has scored for the campaign.
But while Uruguay are favourites at home, this Colombian side - ranked third by FIFA - is certainly good enough to get a result away from home, particularly knowing even a draw is good enough for them to book their tickets to Brazil next year.
Uruguay are unbeaten at home in qualifying but have drawn three of their matches 1-1 while Colombia have won three times on the road already.
As a result a 1-1 draw is the favoured option in correct score betting at $6 at bet365 while Colombia also look good value in the draw no bet market at $2.50 - where punters get their money back if the game ends in a draw.
In other games Argentina should book their place at next year's World Cup by winning away at $1.72 at bet365 against struggling Paraguay at $4.75, while Ecuador should also win at $2.20 away to another team out of contention in bottom-placed Bolivia at $3.30.
The other game is tougher to predict sixth-placed Venezuela and seventh-placed Peru but we will go for Venezuela at home at $2.05 at bet365 with the draw paying $3.35 and the visitors priced at $3.75.
*Note prices subject to change