The Portuguese teenager became City's youngest goalscorer when he came off the bench to seal a 3-0 FA Cup third-round victory against Watford just over a year ago.
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The City starlet impressed in a 3-0 Capital One Cup semi-final second leg win at West Ham on Tuesday after being given the opportunity to start by manager Manuel Pellegrini.
And Lopes is eager to catch the eye once again this weekend, as free-scoring City attempt to stretch their unbeaten run to 19 games in all competitions.
City are still in the hunt to win four trophies this season and they have been in ominous form, winning 16 and drawing two of their last 18 matches.
Alvaro Negredo is not expected to be risked against Watford after injuring his shoulder at Upton Park in midweek, so Edin Dzeko could return to the starting line-up.
Pellegrini is also expected to ring the changes again, with Stevan Jovetic hoping to make his first start since October for a City side that have scored an incredible 68 goals in 17 home games this term.
Watford have not won away from home since October and face a daunting task at the Etihad Stadium.
Giuseppe Sannino's side are 15th in the second tier and they will be without defender Fitz Hall due to suspension.
Midfielder Alexander Merkel completes his three-match ban, while Tommie Hoban and Essaid Belkalem (both ankle) are set to miss out once again along with fellow defender Marco Cassetti (knee).