The Dutchman says the two strikers "can both end up with a lot of goals" this season and says Sunday's clash with Manchester City is a massive game for both sides
After a summer of speculation surrounding his future Rooney remains at Old Trafford and bagged his 200th goal for the club in the midweek win over Bayer Leverkusen.
And Van Persie, who has also started the season in blistering form, says they make a great pairing up front.
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"I think everyone can see we want to play together, that we are trying to give the ball.
"For example, the ball that just missed me in the second half [against Leverkusen] when it went past me, he [Rooney] wanted to pass.
"Everyone could see that. It is good; it goes both ways. I really think if we can keep on growing, keep on passing each other the ball, we can both end up with a lot of goals this year."
The duo face Manchester City on Sunday and Van Persie says although it is still only September, it is a crucial clash for both teams.
"I personally never think in negatives, but I think for both sides it is really important to stay close to the top," he added. “If you lose you might be six points behind already. It’s a lot. So we don’t want that."
"The games come really quick and we love it. This is what we are used to, this is our rhythm, a game every three or four days.
"The Champions League has started which we really like. Sunday is a massive game."
The former Arsenal striker is also impressed with new signing Marouane Fellaini after he made his first start for the club in the Champions League victory at Old Trafford.
"He [Fellaini] looks very all-round to me, he can defend, he’s tough, he can make a tackle; he can really find a pass, between the lines, which is very important for the boys up front," Van Persie added.
"He can head a ball, he can help us with set pieces offensively and defensively."