The Belgian winger missed the 1-0 win over Manchester United on Saturday but returns to the side in place of Victor Moses, while Frank Lampard and John Terry are on the bench
Hazard replaces Victor Moses in attack, while Benitez has also made two other changes from the side which picked up a vital 1-0 victory over Manchester United at Old Trafford on Sunday.
Frank Lampard and Demba Ba join Moses on the bench, while Gary Cahill and Fernando Torres come back into the team, with a win all but confirming a top four finish for Chelsea.
Spurs boss Andre Villas-Boas makes his first return to Stamford Bridge since being sacked by the club last season, and he has also named three changes from the team he picked for their last fixture.
Aaron Lennon, who had been tipped to miss out due to a knock, starts on the right, but Mousa Dembele has not even made it on to the bench as he recovers from an injury, with Scott Parker replacing him.
Jermain Defoe started against Southampton but is replaced in the starting XI to face Chelsea by Emmanuel Adebayor, while Lewis Holtby comes in for Clint Dempsey in midfield.
Chelsea: Cech; Azpilicueta, Ivanovic, Cahill, Cole; Ramires, David Luiz; Oscar, Mata, Hazard; Torres.
Subs: Turnbull, Terry, Lampard, Ake, Moses, Benayoun, Ba.
Tottenham: Lloris; Walker, Dawson, Vertonghen, Assou-Ekotto; Huddlestone, Parker, Holtby; Lennon, Adebayor, Bale.
Subs: Friedel, Caulker, Naughton, Carroll, Dempsey, Sigurdsson, Defoe.