The former West Brom boss this week confirmed his squad to face Brazil in a friendly to kick off the FA's 150th anniversary year, with youngsters such as Phil Jones, Jordan Henderson and Wilfried Zaha all dropping down to the Under-21 squad to face Sweden at Walsall on Tuesday.
Hodgson, however, says that Wilshere is in a different class to the other young Englishman and is now an important part of the senior set-up.
"It is not right to compare Jack with [Wilfried] Zaha, [Raheem] Sterling and [Jonjo] Shelvey, etc," Hodgson told Sky Sports.
"You have to give Wilshere the credit that he has established himself as a bona fide first-team player."
The England manager also dismissed suggestions that the Under-21 tournament added an unecessary burden to youngster insisted they still have plenty of time to rest in the summer.
|9/1||England are 9/1 to beat Brazil 2-1 with bet365|
He added: "Tournaments are played at the end of a football season; how do you avoid the players not having played a long season before, unless it is being suggested that anyone picked doesn't play for their clubs for five or six weeks beforehand? I don't think that would be very popular.
"The U-21 tournament finishes in the middle of June. I don't think the Premier League kicks off again in the middle of August.
"Two months is a long time. Quite a lot of people in normal jobs wouldn't mind two months of not having any real pressure to perform."