Top scorer Robin van Persie on on the bench for the visitors as Chicharito and Danny Welbeck lead the line against Sam Allardyce's men at Upton Park
As expected Sir Alex Ferguson has made several changes for the game against the Hammers with Chris Smalling, Nemanja Vidic, Alexander Buttner, Paul Scholes and Danny Welbeck all coming in.
The hosts, meanwhile, put Joe Cole straight into the side while Kevin Nolan and Alou Diarra also return and Ricardo Vaz Te and Carlton Cole continue up front.
West Ham starting XI: Jaaskelainen; Demel, Collins, Tomkins, Potts; Diarra, Nolan, Collison, Joe Cole; Vaz Te, Carlton Cole
Subs: Spiegel, Reid, Jarvis, Taylor, Noble, Spence, E.Lee
Manchester United starting XI: De Gea; Smalling, Vidic, Evans, Buttner; Rafael, Scholes, Cleverley, Kagawa; Chicharito, Welbeck
Subs: Lindegaard, Ferdinand, Valencia, Giggs, Young, Van Persie, Macheda