Arsene Wenger has named an unchanged eleven from the midweek 5-2 victory at Reading.
The Gunners boss has kept faith with contract rebel Theo Walcott up front, with Olivier Giroud left out of the squad.
Gervinho finds himself on the bench, alongside the newly committed Carl Jenkinson and Aaron Ramsey, who both signed long-term contracts this week.
For Wigan, Shaun Maloney and Franco Di Santo both start after being used as substitutes last weekend, changing places with Jordi Gomez and Mauro Boselli.
The Latics defence finds itself strained. David Jones is introduced to the back three, with both Gary Caldwell and Ivan Ramis short of full fitness.
James McCarthy, however, is deemed fit for the game, despite being brought off against Norwich last week at half time with a knock on his foot.
Wigan starting XI: Al Habsi; Boyce, Jones, Figueroa; McArthur, Stam, McCarthy, Beausejour; Maloney, Di Santo, Kone.
Subs: Pollitt, Caldwell, Gomez, McManaman, Boselli, Fyvie, Golobart.
Arsenal starting XI: Szczesny; Sagna, Mertesacker, Vermaelen, Gibbs; Arteta, Wilshere, Cazorla; Oxlade-Chamberlain, Walcott, Podolski.
Subs: Mannone, Jenkinson, Koscielny, Coquelin, Ramsey, Arshavin, Gervinho.