Paul Scholes doesn't return to action despite serving a suspension and Ashley Young starts whilst wingers Luis Nani and Antonio Valencia remain sidelined with their injuries.
Ryan Giggs is on the bench after shaking off a hamstring complaint whilst Darren Fletcher starts once again in central midfield alongside Michael Carrick.
Paul Scholes doesn't even make the bench despite serving his suspension and Sir Alex Ferguson choses to leave Javier Hernandez on the bench as Wayne Rooney and Robin Van Persie partner eachother upfront.
Reading once again are without Jimmy Kebe who is still recovering from a groin injury which has already kept him out for 3 weeks.
Midfielder Danny Guthrie makes the bench after suffering with a thigh problem for the majority of November and Adam Le Fondre once again starts alongside Jason Roberts.
Reading starting XI:Federici; Cummings, Shorey, Mariappa, Morrison; Leigertwood, Tabb, McAnuff (c), Robson-Kanu; Le Fondre, Roberts
Subs: Taylor, Pearce, Harte, Guthrie, McCleary, Hunt, Pogrebnyak
Manchester United starting XI: Lindegaard, Rafael, Ferdinand, Evans, Evra, Carrick, Fletcher, Anderson, Young, Rooney, van Persie
Subs: De Gea, Jones, Smalling, Cleverley, Giggs, Hernandez, Welbeck