West Ham must face their London rivals Chelsea without striker Andy Carroll, who scored his first goal last Sunday against Tottenham. Carlton Cole therefore comes into the side to start as the Hammers' striker.
Mohamed Diame only manages a place on the bench, with James Tomkins being favoured ahead of the midfielder in the starting XI.
Chelsea go into the game with Branislav Ivanovic playing at centre-back, as John Terry still recovers from his injury alongside Frank Lampard and Daniel Sturridge who also miss out.
Oriol Romeu drops to the bench with Ryan Bertrand and Oscar, whilst David Luiz misses out completely. They make way for Gary Cahill, Jon Obi Mikel, Juan Mata and Victor Moses.
The champions of Europe go to Upton Park still looking for their first win under Rafa Benitez, though despite failing to score since the Spaniard took over from Roberto Di Matteo, Chelsea are also yet to concede.
West Ham: Jaaskelainen; Demel, Collins, Reid, O'Brien; Tomkins, Noble; O'Neil, Nolan, Jarvis; Cole
Subs: Spiegel, Maiga, Taylor, Diame, Spence, Fanimo, Moncur
Chelsea: Cech; Azpilicueta, Ivanovic, Cahill, Cole; Ramires, Obi Mikel; Moses, Mata, Hazard; Torres
Subs: Turnbull, Romeu, Oscar, Ferreira, Marin, Bertrand, Piazon