Brendan Rodgers recalls his Spanish goalkeeper as well as Suso as the Anfield outfit aim to get revenge on Roberto Martinez's Latics team, who remain unchanged from last weekend
Jose Enrique's impressive performance in the wide left position also sees him retain his position in Brendan Rodgers' side as the Anfield club look set to play 3-4-3 against the Latics. Further forward, Suso joins top goalscorer Luis Suarez and recent England debutant Raheem Sterling in an attacking trident.
Elsewhere, Roberto Martinez names an unchanged XI from the side that lost 2-1 at home to West Brom last weekend as he takes on the club he reportedly rejected during the summer. Goalscorer Arouna Kone partners Franco Di Santo as the Latics look to get back on track in the Premier League.
Wigan's last away game saw them defeat Tottenham 1-0 and they have history at Anfield, winning 2-1 last season thanks to a Gary Caldwell winner.
Liverpool: Reina, Wisdom, Johnson, Agger, Skrtel, Allen, Gerrard, Enrique, Suso, Sterling, Suarez.
Subs: Jones, Sahin, Cole, Henderson, Coates, Carragher, Shelvey.
Wigan: Al Habsi, Ramis, Caldwell, Figueroa, Boyce, Beausejour, Watson, McCarthy, Maloney, Di Santo, Kone
Subs: Pollitt, Jones, Gomez, McManaman, Boselli, Stam, Miyaichi