The Socceroo centre-back will play no part in the Wanderers' ACL last-eight clash with Guangzhou Evergrande and must also withdraw from the A-League All Stars squad
The Socceroo will have surgery on Monday to fix an ankle complaint, though we understand it's not a serious injury.
It means the talented central defender will also miss the A-League All Stars clash with Juventus on August. A replacement will be announced soon.
The 26-year-old will also miss the Socceroos' clash with Belgium in early September.
Spiranovic was one of the stars of the Socceroos' Brazil 2014 campaign and was a key contributor to the Wanderers last season - his first in the Hyundai A-League.