The Reds are expected to see off the visit of the title holders when the two finals hopefuls clash in South Australia in the opening match of Round 19
The South Australian side have lost just once in their last eight matches, climbing to fifth on the table, just three points back from the third-placed Mariners.
Josep Gombau's hosts are priced at $2.25 at bet365 to win at Coopers Stadium on Friday night, where the draw is paying $3.25.
Central Coast meanwhile come into this game off the back of a painful 3-1 loss at home to Melbourne Victory, and are out to $3.25 to win.
Adelaide kick-started their good run of form with a thumping 4-0 win at home to the Mariners in December, and you can get a lengthy $41.00 on them repeating the feat this weekend.
If you fancy the Mariners to hold their own early on, a half-time draw and full-time Adelaide win is paying $5.50.
Reds frontman Bruce Djite looks a little short at $6.50 to open the scoring, with playmaker Marcelo Carrusca a better value bet at $12.00 to find the back of the net first in the game.
Matt Simon at $8.50 is the shortest priced Mariner in that market, with new South Korean playmaker Kim Seung-Yong paying $4.33 to score at any time in what could be his Central Coast debut.