The Blaugrana defender believes his side can already start thinking about reclaiming their Liga title this season after earning a 4-1 win over Atletico Madrid
The Catalan club hold a nine-point lead over Diego Simeone's men at the top of the table thanks to Sunday's result, with defending champions Real Madrid trailing by 13.
"La Liga is only ours to lose," he is quoted as saying by AS.
"We're in a very favourable position, but we cannot lose a game. If we relax, the danger is that we go into a run where we don't win two or three games and lose our advantage.
"If we lose a game, nothing happens, but we cannot have a losing streak. We're having a great season. It's something else to watch my team-mates."
Pique went on to say that Atletico, and Radamel Falcao in particular, were tough opponents, and admitted that the match might have been different had Adriano not cancelled out the Colombian's opener.
"The first half took it out of us," he continued. "Adriano's goal gave us a lot. We had a very good game against a great team who are second.
"[Falcao] is a great player - he's having a great season. He runs a lot, so you have to be wary. He's very difficult on the field."