After a 0-0 draw with Scotland, all eyes were on the Eastern Europeans to pick up a positive result at home - a task which they carried out with gusto
Aleksandar Kolarov opened the scoring with a trademark free kick before some unconvincing defending allowed Zoran Tosic to double the hosts' advantage.
Gareth Bale gave the Dragons a boost with a spectacular set-piece goal on the half-hour mark, but Serbia's two-goal advantage was soon restored by Filip Duricic.
More woeful defending led to a fourth goal for the Serbs, Branislav Ivanovic providing the assist for a Dusan Tadic tap-in before the towering Chelsea defender netted one of his own after 80 minutes to bring the tally to five.
Still not content, Miralem Sulejmani completed the 6-1 rout with mere seconds to go, leaving Chris Coleman's side with plenty to think about before their next round of qualifying matches.