The Italian is already a hero in Wiltshire after leading the Robins to promotion in his first season in management, and this game provides an opportunity for his team to show that they can cut it against superior opposition before their League One campaign kicks off on Saturday.
However, his Uruguayan counterpart has also won numerous admirers for instilling a successful brand of attractive football at Brighton, and his side are slight 7/5 (2.40) favourites with Bet365 to emerge victorious this evening.
Swindon's title-winning season was built on an impeccable record at the County Ground, where they have gone a year without losing a competitive match.
Considering Brighton's away record is patchy at best, an upset could certainly be on the cards this evening.
You can back Swindon to overcome their Championship opponents in normal time at odds of 19/10 (2.90), but you may be better off going for the safer option of the Robins winning the tie at 11/10 (2.10).
The two teams have not drawn a game in their last nine encounters, but you can get odds of 23/10 (3.30) on that run coming to an end today.
Perhaps surprisingly for a flamboyant former striker, Di Canio has forged his success at Swindon on a water-tight defence.
The Robins boasted League Two's meanest unit at the back last season, with only 32 goals conceded in 46 league games.
This record was particularly pronounced at home, where the champions did not let in a single goal in their last nine home games last season.
With Gus Poyet still searching in vain for a new striker to bolster a Brighton attack that struggled for goals on the road last year, Swindon could be set for yet another clean sheet tonight, available at a tempting 11/4 (3.75).
|Swindon to win the tie at 11/10 (2.10) with Bet365
||Swindon to keep a clean sheet at 11/4 (3.75) with Bet365|
Sign up with Bet365 for up to £250 in free bets
Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.
Follow GoalBetting on