The assistant to Jose Mourinho insisted that Los Blancos have not grown complacent and is not sure what to expect when they face Villarreal at El Madrigal on Wednesday
The Blaugrana are now eight points behind Madrid after Jose Mourinho's men were held to a 1-1 draw by Malaga at the weekend, but Guardiola reiterated that it is 'impossible' to catch Los Blancos.
"Sometimes in football, people say things they do not mean," Karanka said during a press conference. "He must know why he said that.
"We have to think about Wednesday's match against Villarreal and look at ourselves, not at what is coming from the outside."
The draw against Malaga is the first time that Madrid have dropped points in La Liga in the calendar year, but Karanka disputed the perception that his side have taken their foot off the pedal.
"There have been some good moments and not so good ones, but nothing has changed," Karanka added.
"As the season wears on, collecting points gets even more decisive and it gets harder to win matches.
"Things are going well for us and we have to continue like this. We work the exact same way, whether we are 10, 12, six or one point clear at the top."
When asked about Wednesday's match, the assistant to Jose Mourinho noted that he is in the dark about how Villarreal will approach the game, after the Yellow Submarine appointed Miguel Angel Lotina as coach on Monday.
"We do not know what kind of Villarreal we will find," he explained. "It will not be the Villarreal of [Manuel] Pellegrini, [Juan Carlos] Garrido or [Jose] Molina."
Karanka also commented on the controversy surrounding Fabio Coentrao, who was pictured smoking outside a restaurant on his birthday.
"That is an internal matter of the club and it will be treated as such," he noted.