Antonio Conte will expect a response from his players as they seek to bounce back from their midweek Europa League defeat at Benfica
Relegation-threatened Sassuolo could face a backlash from Juventus when they host the Serie A leaders on Monday.
Eusebio Di Francesco's side have moved out of the dropzone due to an impressive resurgence in the last three games, beating Atalanta and Chievo and earning a draw with Cagliari.
They face a stern test in attempting to continue their good run of form against leaders Juventus, who head into the game on the back of a disappointing result in Europe in midweek.
The Turin giants slipped to a 2-1 defeat at Portuguese champions Benfica in the Europa League semi-final first leg on Thursday, so they will have to come from behind to reach the final at their own Juventus Stadium next month.
Coach Antonio Conte will expect a response from his side on Monday, as they close in on another Scudetto.
Roma cut Juve's lead at the summit to five points with a 2-0 success against AC Milan on Friday and the capital club will be hoping Sassuolo do them a favour by securing a shock triumph.
However, the prospects of Di Francesco's men consigning the champions to only their third league loss of the campaign would appear slim, especially considering the heavy defeat Conte's side inflicted on them in the reverse fixture.
Juve were comprehensive 4-0 winners on that occasion back in December, with Carlos Tevez scoring a hat-trick.
Sassuolo will face a near fully-fit Juve squad at Stadio Citta del Tricolore, with midfielder Arturo Vidal their only absentee because of a knee injury which reportedly could require surgery.
Meanwhile, the hosts will be without three key players due to suspension: top scorer Domenico Berardi is banned, while midfielders Davide Biondini and Simone Missiroli are also suspended.