The F3 derby takes in its latest instalment, but - despite the Jets' victory last time the sides met - it is the visitors who are heavily favoured.
Neville, Regan, Chapman, Ritter
Zadkovich, Grossman, Brown
Bernardo, Heskey, Goodwin
CENTRAL COAST MARINERS
Bojic, Sainsbury, Anderson, RoseMcGlinchley, M'gomery, Hutchinson
Ibini, McBreen, Bozanic
With Ben Kantarovski out of action following knee surgery, central defender Tiago Calvano also on the treatment table and Josh Mitchell and Ryan Griffiths suspended, Jets head coach Gary van Egmond will be forced into several changes for the visit of Central Coast Mariners.
Van Egmond has hinted that Taylor Regan will partner Connor Chapman in the centre of Newcastle's back four, while Craig Goodwin will most likely replace Griffiths on the left wing.
In the middle of the park, Wheelhouse's injury may give Chris Grossman an opportunity to play, after the former North Queensland Fury player was signed on a short-term contract to cover for Kantarovski. Jacob Pepper may be another option.
Newcastle's injury and suspension woes could not come at a worse time, as local rivals Central Coast are on a six-game unbeaten run and moved to the top of the A-League ladder last week after a 2-1 win over Adelaide United.
While Central Coast head coach Graham Arnold will still be without Tom Rogic and Mat Ryan due to international duty, the Mariners should be confident of overturning their home loss to the Jets in Week 3.
Former Australia international Mile Sterjovski is back in the squad, but Arnold may elect to continue with the XI that began in the win over Adelaide.
After a cracking start to the A-League season, Newcastle have won only once in their past five matches.
Marquee striker Emile Heskey has scored five goals this season but in the Jets' poor period only hit the back of the net in that 2-1 triumph away to Western Sydney in Week 6.
Can Newcastle find a way to help the 34-year-old back into form and simultaneously turn the club's season around?
Dutch defender Patrick Zwaanswijk, meanwhile, has been central, both figuratively and literally, to the Mariners' defensive structure in his three seasons with the club.
Zwaanswijk, 37, was suspended against Brisbane Roar a fortnight ago and was kept out by the impressive performance from Trent Sainsbury and Zac Anderson in the win over Adelaide. Will Arnold be tempted to bring back the big Dutchman for the pressure of the F3 Derby?
While Newcastle will be hopeful of a positive result, given they are the only side to defeat Central Coast this season, the visitors look likely to have too much quality at Hunter Stadium.