The arrival of Postecoglou at Victory have revived fans' confidence after a torrid last season, while Heart are tipped by many to struggle this season. What will be the outcome?
Foschini, Milligan, Leijer, Traore
Bru, Finkler, Broxham
Rojas, Flores, Thompson
Marrone, Gray, Colosimo, Behich
Gerhardt, Garcia, Thompson
Fred, Tadic, Dugandzic
Since Victory overcame Heart 3-1 in the two clubs' second-ever meeting, the red half of Melbourne have not lost to the two-time champions.
Victory head into the seventh derby on the back of some mixed results, hitting four goals past both a Tasmanian XI and Adelaide United and being held to a 1-1 draw by Central Coast Mariners, before grand finalists Perth Glory handed them a 2-1 loss in their final pre-season hit out.
Heart began their pre-season with wins against Northcote and a Peninsula XI but fell to a crushing 5-0 loss against Central Coast in their final pre-season game.
Victory should be at full strength with captain Adrian Leijer expected to be included, while Heart have several injury doubts in Jonatan Germano [ankle] and Golgol Mebrahtu [groin].
They are expected to miss.
Off-season signing Marcos Flores is a danger man for Victory; the charismatic Argentine's flair and attacking brilliance that saw him win the 2011 Johnny Warren Medal will worry new Heart boss John Aloisi.
Aloisi's new signing Richard Garcia is another to watch. The former Australia internationall's wealth of experience could help form a formidable midfield partnership with captain Fred.
Ange Postecoglou's arrival and the influx of players has Victory as one of the championship favourites.
Slow starters, Heart failed to win any of their two opening day matches, and will start as underdogs on Friday.