Perth will be hoping for some better fortune when they return to Melbourne, with both clubs in desperate need of full points at AAMI Park.
Walker, Gerhardt, Colosimo, Mitchinson
Kalmar, Fred, Thompson
Williams, Tadic, Hoffman
Risdon, V.d. Brink, Pantelidis, Heffernan
Dodd, Miller, Burns, Zahra
Heart coach John Aloisi will again have to do without Socceroos Michael Marrone, Aziz Behich and Richard Garcia, who are away on East Asian Cup duties.
Heart often looked exposed in wide areas against Sydney and, in truth, were lucky to escape with a 0-0 draw on Sunday.
Teenage trio Ben Garuccio, 19-year-old debutant Jeremy Walker and Sam Mitchinson deputised in the wide areas for Aloisi's side and the latter two will likely have to do so again.
Garuccio suffered a nasty injury following a tackle from Fabio, a card-less incident that incensed Aloisi given his already threadbare squad, and he may not feature as a result.
Winger Mate Dugandzic remains sidelined for at least another two months with a broken foot, making the trio's absence all the more glaring. Walker became the first Tasmanian graduate to appear in the competition and will slot into defence again.
The Glory fought hard at AAMI Park against Melbourne Victory but were ultimately undone by a piece of Marco Rojas magic in a 1-0 defeat - Perth's fourth consecutive game without a win.
But Perth too, are without internationals in Scott Jamieson and Michael Thwaite, although captain Jacob Burns is set to return from suspension. Liam Miller may be available after he was a late withdrawal last Friday with back soreness.
Inexperience and injuries aside, Heart could be just one more poor result away from last place on the table if Sydney manage to defeat Wellington.
Much of the side's strengths lie down the flanks, where Behich and Marrone provide plenty of avenues forward as well as defensive cover, which Heart will again have to make do without.
Striker Josip Tadic will need to have his shooting boots on as will captain Fred, given Heart's worrying habit of giving up home leads.
Last season's grand finalists Perth, meanwhile, would not have expected to pick up just a point in consecutive home matches against Western Sydney and Wellington ahead of a tricky double header in Melbourne.
In an even league, a run of four winless matches - five if they fail to defeat Heart - will cost you dearly.
Perth lie two points above Heart in sixth but are in danger of dropping as low as second last. How things can change.