Both sides are eyeing early qualification to the AFC Champions League's knockout stages, but it is the Reds at home who perhaps hold favouritism in this match
Bunyodkor and Adelaide United need little introduction, and it is the Reds who foster the best memories when the Uzbek League champions visit Hindmarsh Stadium in the AFC Champions League on Wednesday.
The venue was the scene of an unlikely 3-0 victory in the 2008 tournament, with the Reds setting up their semi-final victory thanks to goals from Diego Walsh, Fabian Barbiero and Cristiano.
Bunyodkor won their ensuing home leg 1-0 but it was United who progressed to the final, and it was Adelaide who took bragging rights with a confidence-building 2-1 win over the Tashkent side in the corresponding Group E match earlier in this year's tournament.
It might have been a domestic season to forget for Adelaide, but the Reds are on another fairytale run in the AFC Champions League.
Group E leaders following wins over each of the other three teams drawn with them in Bunyodkor, Gamba Osaka and Pohang, United will advance to the knockout stage of the competition if they do not lose to Bunyodkor in their penultimate match.
Bunyodkor are enjoying a successful start to their new season, sitting equal top of the Uzbek League table and second in Group E.
It seems to have been clicking in the final third for the Swallows, having scored 24 goals in their last 10 games across all competitions.
In fact, not once in 2012 has a team been able to stop Bunyodkor from finding the back of the net - that includes their two pre-season friendlies against Wolfsburg and Zenit, as well as in the ACL and their domestic league and cup.
Star Adelaide pair Dario Vidosic and Sergio van Dijk face fitness tests ahead of the match, while neither of the Reds' new signings Daniel Bowles and Jake Barker-Daish are registered for this stage of the competition.
Bunyodkor, meanwhile, have few fitness concerns.