The veteran coach has been doing extra preparation for his side's clash with Oranje and believes they remain just as dangerous with their new-look squad
The world and European champions were drawn in the same group as Oranje, whom they beat in the final in the last edition of the tournament, for the competition this summer.
Del Bosque has revealed that he has been watching a lot of Louis van Gaal's side to best prepare his side for their match.
"We respect the Dutch and the style they use, despite the changes of the past four years," he told NOS.
"That's the team that we have the most watched in the preparation. There are still major players associated with the very best clubs."
Del Bosque went on to say that he is not expecting Real Madrid and Atletico Madrid's lengthy Champions League runs to have an adverse on his side.
"For us, football is beautiful," he added.
"It is an exceptional success and it shows that our clubs are in good shape. I think Atletico have surprised everyone. Only big optimists had thought that they would come this far."